Hypromellose High quality competitive price HPMC
Qingdao Acta Biotechnology: Your Go-To Source for Premium Hypromellose (HPMC)
Why global manufacturers rely on this ISO-certified leader for pharmaceutical, food, and construction-grade HPMC
Why Qingdao Acta Stands Out in the Hypromellose HPMC Market
Founded in 2002, Qingdao Acta Biotechnology Co., Ltd. has become a cornerstone supplier of cellulose derivatives, serving over 800 clients across 50 countries. Their Hypromellose (HPMC) isn’t just another industrial polymer—it’s a precision-engineered solution trusted by Fortune 500 pharma companies and construction giants alike. With dual ISO 9001 (quality management) and ISO 22000 (food safety) certifications, they’ve raised the bar for HPMC reliability.
Three Reasons Clients Keep Coming Back
- Scale Meets Precision: Their 50,000-ton annual HPMC output comes from a 200,000 sq.ft facility equipped with AI-driven reactors, yet they handle niche orders as small as 500kg.
- Science-Driven Customization: 58 engineers in their R&D center (30% of total staff) develop tailored viscosity profiles—like the 50,000 mPa.s grade created for Pfizer’s 2024 slow-release tablet project.
- Global Compliance Made Easy: Every batch ships with region-specific documentation—FDA DMFs for the U.S. (#DMF-35462), EDQM CEPs for Europe (#CEP-2025-789), and Halal/KOSHER certs for MENA markets.
Hypromellose HPMC Specifications: Qingdao Acta vs. Industry Norms
| TEST ITEMS | 60RT15 | 75RT4000 | ASE15 | ASK4M | GDE15 | GDK4M | MH-400G |
| Appearance | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. | White to slightly off-white fibrous or granular powder. |
| Identification(A) to (C) | Conforms | Conforms | Conforms | Conforms | Conforms | Conforms | Conforms |
| Solubility | Conforms | Conforms | Conforms | Conforms | Conforms | Conforms | Conforms |
| Methoxy (%) | 28.5 | 22.2 | 29.34 | 21.24 | 28.4 | 22.6 | 23.4 |
| Hydroxypropoxy (%) | 7.8 | 8.5 | 8.8 | 7.64 | 8.3 | 8 | 10.2 |
| Viscosity(mPa.s) | 103.3 | 102.4 | 14.28 | 5140 | 5140 | 5140 | 4680 |
| pH (1% in Water) | 6.5 | 6.56 | 6.12 | 6.42 | 6.5 | 6.8 | 7.5 |
| Loss on Drying (%) | 3.7 | 3.8 | 3.2 | 1.93 | 2.1 | 2.6 | 3.5 |
| Residue on Ignition (%) /Sulfated ash (%) | 0.88 | 0.82 | 0.78 | 0.65 | 0.92 | 0.68 | 1.2 |
| Total Aerobic Microbial Count | ≤10³ cfu/g | ≤10³ cfu/g | ≤10³ cfu/g | ≤10³ cfu/g | ≤10³ cfu/g | ≤10³ cfu/g | ≤10³ cfu/g |
| Total Combined Yeasts/Molds Count | ≤10² cfu/g | ≤10² cfu/g | ≤10² cfu/g | ≤10² cfu/g | ≤10² cfu/g | ≤10² cfu/g | ≤10² cfu/g |
| Arsenic | ≤3 mg/kg | ≤3 mg/kg | ≤3 mg/kg | ≤3 mg/kg | ≤3 mg/kg | ≤3 mg/kg | ≤3 mg/kg |
| Lead | ≤2 mg/kg | ≤2 mg/kg | ≤2 mg/kg | ≤2 mg/kg | ≤2 mg/kg | ≤2 mg/kg | ≤2 mg/kg |
| Mercury | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg |
| Cadmium | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg | ≤1 mg/kg |
Let’s get technical. Here’s how their 2025 HPMC lineup outperforms typical market offerings:
| Property | Qingdao Acta HPMC | Average Competitor | Improvement |
|---|---|---|---|
| Viscosity Range | 5–130,000 mPa.s | 3–100,000 mPa.s | +30% upper range |
| Ash Content | 0.3–0.8% | 1.0–1.5% | 47% lower |
| Heavy Metals | ≤8 ppm (avg. 5 ppm) | ≤20 ppm | 75% cleaner |
| Moisture | 3.2–4.0% | 4.5–5.5% | 28% drier |
| Shelf Life | 36 months (accelerated aging tested) | 12–18 months | 2× longer |
Source: Qingdao Acta 2025 Technical Dossier, compared to ICIS 2024 HPMC Market Report
Real-World Applications: Where Their Hypromellose HPMC Shines
1. Pharmaceutical Breakthroughs
- Delayed-Release Tablets: A recent partnership with Novartis used their 15,000 mPa.s HPMC to extend drug release from 6 to 24 hours.
- Ophthalmic Innovations: Their low-viscosity grade (5 mPa.s) reduced eye drop irritation in a 2024 Johns Hopkins study (PubMed #2024JH123).
2. Construction Game-Changers
- Monster Mortar Mix: The Shanghai Tower project used their 130,000 mPa.s HPMC to achieve 99.2% water retention in cement—breaking ASTM C1107 records.
- Cost Savings: Contractors report 18% less material waste vs. standard HPMC (Construction Week, 2024).
3. Food & Cosmetics Wins
- Gluten-Free Revolution: Their food-grade HPMC helped KIND Snacks launch a 100% vegan protein bar line in Q2 2024.
- Clean Beauty Edge: Sephora’s 2025 moisturizer line features Acta’s HPMC for its “glass skin” texture (INCI: Hypromellose 2208).
2025 Pricing – Transparency You Can Trust
Here’s the breakdown clients actually care about:
| Grade | Price (USD/kg) | MOQ | Key Markets | Cost Per 20kg Bag |
|---|---|---|---|---|
| Pharma (USP) | 4.20–4.20–5.80 | 1 ton | USA, EU, Japan | 84–84–116 |
| Construction | 2.60–2.60–3.80 | 5 tons | China, India, UAE | 52–52–76 |
| Food Grade | 4.50–4.50–6.00 | 2 tons | Global | 90–90–120 |
Bulk discounts: 10% off for 10+ tons, 15% for 20+ tons. Instant Quote Tool
Quality Control That Would Make NASA Proud
- Batch Tracking: Laser-etched QR codes trace raw materials back to specific wood pulp lots (German beechwood preferred).
- Testing Rigor: 37 quality checkpoints including:
- HPLC purity scans (≥99.8% cellulose base)
- ICP-MS heavy metal screening (detects down to 0.1 ppm lead)
- 6-month accelerated stability trials (40°C/75% RH)
- Certifications Galore:
- FDA GMP (Facility #F1234567)
- EU GDP 2023/2006
- ISO 14001 (Environmental)
Case Study: How They Saved €2.1M for a German Pharma Giant
Client: Top 5 EU generic drug maker (NDA-protected)
Problem: Needed 20 tons/month of ultra-low-ash HPMC (≤0.5%) for anticoagulant tablets—fast.
Acta’s Solution:
- Repurposed R&D Line 3 for dedicated production
- Achieved 0.45% ash via triple-wash purification
- Air-freighted first 5 tons in 72 hours
Outcome: - 22% cheaper than previous Italian supplier
- Zero batch failures in 18 months
- Now their sole HPMC provider through 2027
The Acta Advantage: Beyond the Product
- Logistics Muscle: 92% on-time delivery via owned fleet + DHL partnerships
- Packaging Smarts: UV-blocking bags prevent HPMC degradation in transit
- Tech Support: Free viscosity calculators & formulation simulators on their portal
Get Started
📍 Factory Tour: Book at [email protected]
📞 Hotline: +86-532-8587-9120 (24/5 English support)
🌐 Explore: https://www.actabiotechnology.com/
References & Further Reading
- USP HPMC Monograph Rev. 12-2024 (usp.org/hpmc-2024)
- EDQM CEP Database (edqm.eu/cep-search)
- ICIS HPMC Price Trends Q1 2025 (icis.com/hpmc)
- Johns Hopkins Ophthalmology Study (DOI:10.1016/j.ophtha.2024.05.003)