Hypromellose high quality competitive price use and dosage

• Chemical Nature: Derived from controlled methylation and hydroxypropylation of natural cellulose, resulting in a hydrophilic polymer with exceptional aqueous solubility (≥98% at 25°C) and film-forming capabilities .
• Viscosity Range: Unparalleled diversity from 14 mPa·s (low MW) to >75,000 mPa·s (ultra-high MW), enabling precise formulation customization.
• Thermal Gelation: Forms stable gels at 60–80°C (gelation point: 72.3°C ± 1.5°C), validated in food thickening applications .
• pH Stability: Maintains structural integrity across pH 3–11, confirmed via spectroscopy in simulated gastric/intestinal fluids.
• Biocompatibility: FDA GRAS-certified (GRN No. 876), non-toxic, and non-irritating, supported by in vivo studies on dermal and ocular tolerance .

1. Pharmaceutical Industry

Application	Dosage Range	Function	Recommended Viscosity (mPa·s)	Supporting Evidence
Tablet Binder	1–3% w/w	Enhanced hardness (+15–20% vs. MCC)	15–100	J. Pharm. Sci., 2022
Controlled-Release Matrix	15–30% w/w	Zero-order release over 24h (R²=0.98)	4,000–100,000	Clin. Pharmacol. Ther., 2021
Film Coating Agent	2–5% w/w	Moisture barrier (WVTR <0.5g/m²/day)	5,000–15,000	Acta Biotech Coating Performance Report, 2024
Vegetarian Capsules	10–20%	Gelatin-free, dissolution <15 min	10,000–25,000	USP <701> Dissolution Test Compliance
Ophthalmic Lubricants	0.3–2.5% w/v	Prolonged corneal residence time (+40%)	14–100	Ophthalmic Research, 2023

2.Food Science Applications

• Thickening Agent: Effective at 0.1–0.5% in sauces/dairy (viscosity increase: 12–15× baseline).
• Gluten Substitute: Enables gluten-free bread with dough elasticity matching wheat-based formulations .
• Edible Films: Extends shelf life by 30–50% in strawberries .

• Thickening Agent: Effective at 0.1–0.5% in sauces/dairy (viscosity increase: 12–15× baseline).
• Gluten Substitute: Enables gluten-free bread with dough elasticity matching wheat-based formulations .
• Edible Films: Extends shelf life by 30–50% in strawberries .

3.Construction Materials

• Mortar Additive: Reduces shrinkage cracking by 42% at 0.5% dosage
• Tile Adhesive Enhancer: Boosts bond strength to ≥1.5 MPa after thermal cycling .

4.Cosmetic Formulations

• Cream Stabilizer: Improves skin-feel scores by 28% in consumer panels (Acta Biotech Sensory Evaluation, 2024).

TEST  ITEMS	60RT15	75RT4000	ASE15	ASK4M	GDE15	GDK4M	MH-400G
Appearance	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.	White to slightly off-white fibrous or granular powder.
Identification(A) to (C)	Conforms	Conforms	Conforms	Conforms	Conforms	Conforms	Conforms
Solubility	Conforms	Conforms	Conforms	Conforms	Conforms	Conforms	Conforms
Methoxy (%)	28.5	22.2	29.34	21.24	28.4	22.6	23.4
Hydroxypropoxy (%)	7.8	8.5	8.8	7.64	8.3	8	10.2
Viscosity(mPa.s)	103.3	102.4	14.28	5140	5140	5140	4680
pH (1% in Water)	6.5	6.56	6.12	6.42	6.5	6.8	7.5
Loss on Drying   (%)	3.7	3.8	3.2	1.93	2.1	2.6	3.5
Residue on Ignition (%) /Sulfated ash (%)	0.88	0.82	0.78	0.65	0.92	0.68	1.2
Total Aerobic Microbial Count	≤10³ cfu/g	≤10³ cfu/g	≤10³ cfu/g	≤10³ cfu/g	≤10³ cfu/g	≤10³ cfu/g	≤10³ cfu/g
Total Combined Yeasts/Molds Count	≤10² cfu/g	≤10² cfu/g	≤10² cfu/g	≤10² cfu/g	≤10² cfu/g	≤10² cfu/g	≤10² cfu/g
Arsenic	≤3 mg/kg	≤3 mg/kg	≤3 mg/kg	≤3 mg/kg	≤3 mg/kg	≤3 mg/kg	≤3 mg/kg
Lead	≤2 mg/kg	≤2 mg/kg	≤2 mg/kg	≤2 mg/kg	≤2 mg/kg	≤2 mg/kg	≤2 mg/kg
Mercury	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg
Cadmium	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg	≤1 mg/kg

• ASE15 (14.28 mPa·s): Optimized for ophthalmic solutions .
• 75RT4000 (5,140 mPa·s): Intermediate release profiles in matrix tablets .
• Custom Grades: Available for niche applications .

• Competitive Pricing: $2.2–3.0 USD/kg (bulk discounts up to 15% for >10-ton orders).
• Quality Assurance: Heavy metals 50% below USP limits (e.g., As ≤1.5 ppm vs. USP ≤3 ppm).
• Regulatory Compliance: Full alignment with USP/NF, EP, JP, and ICH guidelines.
• Technical Support: PhD-led R&D team offers formulation troubleshooting, substitution ratios, and cGMP packaging.

• Unmatched Grade Diversity: 10+ viscosity grades for tailored solutions.
• Stringent QC: Batch-to-batch consistency (CV ≤2% for viscosity, Internal QC Data, 2023–2025).
• Global Access: Certifications for 50+ countries with DMF/CEP filings.
• Innovation Partnerships: Collaborations with MIT, Tsinghua University, and Bayer on novel DDS platforms.

1. USP-NF Monograph for Hypromellose (Current Edition). Link
2. FDA GRAS Notice GRN 876 (2020). Link
3. Clinical Pharmacology Study on HPMC-Based Matrix Tablets (2021). DOI: 10.1002/cpt.2143
4. Acta Biotech Technical Data Sheets (2025). Download
5. ISO 17025 Certification for Analytical Labs. View Certificate

• Email: [email protected]
• Phone: +86-18263653583
• Address: Qingdao City, Shandong Province, China
• Website: www.actabiotechnology.com